Background

There is uncertainty in the relationship between exposure to combustion particles and cardiovascular risk for concentrations higher than those typical outdoors in urban areas of high income countries. India is a useful setting for investigating the cardiovascular risk of particles across a wide exposure range, including high exposures. High particle concentrations have been measured outdoors in Indian cities, within vehicles, and in households using solid fuel for cooking.

The aim of this project is to investigate the risk of cardiovascular disease related to particulate air pollution from outdoor and household sources within the Andhra Pradesh Children and Parents Study (APCAPS) prospective cohort.

 

Project objectives

  • To characterize medium-term exposure of participants of the APCAPS cohort to particles using an integrated approach that captures exposure from household and other sources.
  • To use methods for the objective measurement of location and time-activity patterns linked to continuous personal monitoring of particles to identify specific activities and microenvironments important for exposure.
  • To quantify the association between exposure to particles and intermediate endpoints for cardiovascular disease.